Antibody-Initiated Loop-Mediated Isothermal Nucleic Acid Amplification (ai-LAMP) as a New Biosensor for Antigen Detection
Navaporn Sritong, Ana L Claure Dips, Eric Tan, Karin F.K. Ejendal, Tamara L. Kinzer‐Ursem, Jacqueline Callihan Linnes
This paper develops ai-LAMP, a biosensor platform for sensitive protein detection using antibody-initiated loop-mediated isothermal amplification, achieving a 46x improvement in sensitivity for HIV-1 p24 detection compared to existing methods.
bioRxiv · Sep 24, 2025 · PreprintBioengineering