Receptor tyrosine kinase inhibitors trametinib and axitinib effectively target the neoplastic component of giant cell tumor of bone in vitro
Veronika Knechtova, Michal Mahdal, Iva Staniczková Zambo, Dušan Zoufalý, Olga Piskareva, Petr Chlapek, Jan Skoda, Jakub Neradil
This study identifies trametinib and axitinib as effective inhibitors of GCTB stromal cells in vitro, showing selective activity against tumor cells compared to healthy controls.
bioRxiv · Oct 6, 2026 · PreprintCancer Biology