Heterogeneity of the GFP fitness landscape and data-driven protein design
Louisa González Somermeyer, Aubin Fleiss, Alexander S. Mishin, Nina G. Bozhanova, Anna A. Igolkina, Jens Meiler, Maria-Elisenda Alaball Pujol, Ekaterina V. Putintseva, Karen S. Sarkisyan, Fyodor A. Kondrashov
The paper characterizes fitness landscapes of fluorescent proteins and finds that flat landscapes are less suitable for machine learning-based protein design.
eLife · May 4, 2022Peer-reviewedSynthetic Biology