Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern
Andrew K. Lawton, Tyler Engstrom, Daniel J. Rohrbach, Masaaki Omura, Daniel H. Turnbull, Jonathan Mamou, Teng Zhang, Jennifer M. Schwarz, Alexandra L. Joyner
The paper shows cerebellar folding arises from mechanical forces due to uniform cell behavior, not a cellular pre-pattern.
eLife · Apr 16, 2019Peer-reviewedDevelopmental Biology