Cancer BiologyBMC BioinformaticsPeer-reviewed
A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures
Lena Morrill Gavarró, Dominique‐Laurent Couturier, Florian M. Markowetz
This paper introduces a Dirichlet-multinomial mixed model to analyze differential abundance of mutational signatures across clonal and subclonal mutations in cancer, finding significant differences in mutational processes between these groups.