Glenn Hickey

The paper introduces snarls and ultrabubbles for bidirected graphs to represent genomic variations and presents an algorithm for their detection using cactus graphs.

The paper improves the American alligator genome assembly and identifies estrogen-responsive regions linked to female-biased gene expression in post-temperature-sensitive gonads.

This paper introduces genome graphs as an alternative to linear reference genomes, showing they improve read mapping and variant calling compared to the standard GRCh38 reference.

The paper organizes a competitive evaluation of whole genome alignment methods using simulated and real datasets, finding significant accuracy differences between tools and performance variations across evolutionary distances.