Investigating Gene Expression Noise Reduction by MicroRNAs and MiRISC Reinforcement by Self-Feedback Regulation of mRNA Degradation
Shuangmei Tian, Ziyu Zhao, Meharie G. Kassie, Fangyuan Zhang, Beibei Ren, Degeng Wang
The paper uses mathematical modeling and scRNA-seq data to show that miRISC self-feedback regulation of mRNA degradation reduces expression noise at the cost of increased metabolic expenditure.
bioRxiv · Feb 11, 2025 · PreprintSystems Biology