Degeng Wang

This study compares transcription bursting patterns between scaffold and effector proteins in multi-protein complexes, finding that scaffold proteins use more frequent, smaller bursts to maintain homeostatic expression.

The paper uses mathematical modeling and scRNA-seq data to show that miRISC self-feedback regulation of mRNA degradation reduces expression noise at the cost of increased metabolic expenditure.

The paper applies computer science principles of locality and caching to explain transcriptome regulation and cellular efficiency in gene expression.

The paper quantitatively analyzes the coordination of transcriptome regulation mechanisms by measuring transcription rate, mRNA abundance, and translation activity, revealing their statistical relationships and regulatory roles.