Author

Yongheng Wang

Shriners Hospitals for Children - Northern CaliforniaORCID 0000-0002-2372-463XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:large language model· 2 Assay:scRNA-seq· 2 Research Focus:software / tool· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Aijun WangiD· 3 shared Siyu LiniD· 3 shared Weidi ZhangiD· 3 shared Dongyu HuangiD· 2 shared Jia Wang· 2 shared Lizhen ShaoiD· 2 shared Pengcheng TaniD· 2 shared Tai‐Hang LiuiD· 2 shared

Activity by Year

2024-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioinformatics

Aijun WangORCID

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Author profile →

5 papers

Recent·Most cited

Identifying Alzheimer's disease-related pathways based on whole-genome sequencing data

Yongheng Wang, Liu Taihang, Yijie He, Pengcheng Tan, Dongyu Huang, Tong Wen, Lizhen Shao, Jia Wang, Yingxiong Wang, Zhijie Han

This study identifies Alzheimer's disease-related pathways using whole-genome sequencing data, finding 3,798 pathways with 19.7% previously reported and highlighting key pathways like NF-κB signaling and GSK3β activation.

Computational and Structural Biotechnology Journal · Jan 1, 2025Peer-reviewedBioinformatics

Bioinformatics Copilot 2.0 for Transcriptomic Data Analysis

Yongheng Wang, Weidi Zhang, Ian Wong, Siyu Lin, Rohan Kumar, Aijun Wang

Bioinformatics Copilot 2.0 enhances single-cell transcriptomic analysis with internal server processing, user control, real-time information access, and result documentation.

bioRxiv · Aug 15, 2024 · PreprintBioinformatics

TransMetaSegmentation (TMS): a transcriptome-based segmentation method for spatial metabolomic data

Yongheng Wang, Kayle J. Bender, Weidi Zhang, Siyu Lin, Elizabeth K. Neumann, Aijun Wang

This paper introduces TMS, a method that combines MALDI MSI data with single-cell spatial transcriptomics to segment cells and assign metabolites to cell types.

bioRxiv · Jun 12, 2024 · PreprintBiochemistry

Genetic regulation of lncRNA expression in the whole human brain

Yijie He, Yaqin Tang, Pengcheng Tan, Dongyu Huang, Yongheng Wang, Tong Wen, Lin Huang, Jia Wang, Lizhen Shao, Qinyu Cai, Zhimou Li, Yueyang Wang, Tai‐Hang Liu, Zhijie Han

The paper identifies genetic variants influencing lncRNA expression in ten brain regions and links them to neurological disorders like insomnia.

bioRxiv · May 20, 2024 · PreprintBioinformatics

Bioinformatics Copilot 1.0: A Large Language Model-powered Software for the Analysis of Transcriptomic Data

Yongheng Wang, Weidi Zhang, Siyu Lin, Matthew S. Farruggio, Aijun Wang

Bioinformatics Copilot 1.0 provides a natural language interface for analyzing transcriptomic data, reducing the time and expertise required for complex bioinformatics workflows.

bioRxiv · Apr 11, 2024 · PreprintBioinformatics