Jia Wang

Structural analysis reveals three families of bacterial tRNA mimics

The paper identifies three families of bacterial tRNA-like RNAs through structural and genetic analysis, linking one family to sporulation control in Clostridioides difficile.

A kinetic-aware approach to infer metabolic variations and flux using transcriptomics and metabolomics data

This paper introduces mmFEA, a kinetic-aware framework for estimating metabolic flux changes from transcriptomics and metabolomics data, showing improved accuracy over baseline methods.

Structural assemblies for an RNA world

The paper shows short RNAs can form complex structures like icosahedrons and filaments, expanding the known RNA quaternary structures and supporting RNA-based self-assembly in an RNA world.

Integrin beta 4 promotes colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin signaling pathway

This study identifies ITGB4 as a driver of colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin pathway.

RNA sequencing resolves cryptic pathogenic variants in mitochondrial disease

This study uses RNA sequencing to identify pathogenic variants in mitochondrial disease patients who were undiagnosed by DNA sequencing, revealing cryptic splicing and regulatory events.

The structure and catalytic mechanism of new cellular and viral HDV ribozymes

The paper determines the structure and catalytic mechanism of two new HDV ribozymes from a nematode and a virus, revealing a unique Lewis acid mechanism distinct from other ribozymes.

Transcriptomics-based modeling of methionine metabolism effectively estimates sample-wise DNA methylation activity and epigenetic aging

This paper develops TDMA, a transcriptomics-based model to estimate DNA methylation activity and epigenetic aging from bulk, single-cell, and spatial transcriptomics data.

Deep generative models generate mRNA sequences with enhanced translation capacity and stability

GEMORNA generates mRNA sequences with enhanced translation capacity and stability, showing significant improvements in expression levels and therapeutic applications.

Identifying Alzheimer's disease-related pathways based on whole-genome sequencing data

This study identifies Alzheimer's disease-related pathways using whole-genome sequencing data, finding 3,798 pathways with 19.7% previously reported and highlighting key pathways like NF-κB signaling and GSK3β activation.

Genetic regulation of lncRNA expression in the whole human brain

The paper identifies genetic variants influencing lncRNA expression in ten brain regions and links them to neurological disorders like insomnia.

Reconstruction of microbial haplotypes by integration of statistical and physical linkage in scaffolding

PoolHapX reconstructs microbial haplotypes by integrating genetic sharing and genomic sequencing, outperforming existing tools and revealing new insights into HIV evolution.