Leptin: A Potential Adipokine Bridging Systemic Endotoxemia and Sex-Divergent Temporomandibular Joint Osteoarthritis Development
Shipin Zhang, Siyi Chen, Marina Fonti, David Fercher
This study shows chronic LPS exposure causes sex-divergent TMJ OA in rats, with leptin playing a key role in female-specific joint damage and inflammation.
bioRxiv · Oct 13, 2025 · PreprintPathology