Identification and Masking of Artefactual and Misleading Within-Host Variants in Deep-Sequencing SARS-CoV-2 Data
Klara M. Anker, Rosario Evans Pena, Steven A. Kemp, Joseph Clarke, Lele Zhao, David Bonsall, Nicholas E. Grayson, Matthew Bashton, Ann Sarah Walker, Tanya Golubchik, Matthew Hall, Katrina Lythgoe
The paper identifies and masks artefactual variants in SARS-CoV-2 sequencing data to improve the accuracy of within-host diversity and transmission analysis.
Molecular Biology and Evolution · Aug 17, 2026Peer-reviewedGenomics