TopicVI: A Knowledge-guided deep interpretable model for resolving context-specific gene programs
Guoxin Cai, Wenyi Zhao, Xunuo Zhu, Yitao Lin, Binbin Zhou, Jin Cao, Q. Peter He, Bo Yang, Xun Gu, Xushen Xiong, Zhize Zhou
TopicVI identifies context-specific gene programs in single-cell and spatial transcriptomics data by integrating biological knowledge with data-driven refinement.
bioRxiv · Apr 10, 2026 · PreprintBioinformatics