Alzheimer's Disease-Related Mutations in APP Influence Colorectal Tumor Formation in a Sex-Dependent Manner
Takako Ishida-Takaku, Mona Sohrabi, Heidi L. Pecoraro, Colin Kelly Combs
This study shows that Alzheimer's disease-related APP mutations promote colorectal tumor formation in male mice but inhibit it in female mice, with sex-dependent transcriptomic and immune differences.
iScience · Jul 1, 2026Peer-reviewedNeuroscience