Colin Kelly Combs

This study shows that Alzheimer's disease-related APP mutations promote colorectal tumor formation in male mice but inhibit it in female mice, with sex-dependent transcriptomic and immune differences.

The paper compares proteomic profiles of PBMCs from male and female Alzheimer's patients and controls to identify sex-specific differences in disease mechanisms.

This study investigates HLA-II-dependent neuroimmune changes in a mouse model of Group A Streptococcus necrotizing fasciitis, showing that antibiotic treatment reduces neuroinflammation in HLA-II DR3 mice.