Direct prediction of Homologous Recombination Deficiency from routine histology in ten different tumor types with attention-based Multiple Instance Learning: a development and validation study
Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Tobias Seibel, Didem Çifçi, Marko van Treeck, Marco Gustav, Zunamys Itzell Carrero, Nadine Therese Gaisa, Kjong-Van Lehmann, Alexandra F. Leary, Pier Selenica, Jorge Sergio Reis-Filho, Nadina Ortiz Bruechle, Jakob Nikolas Kather
This study uses attention-based multiple instance learning to predict HRD status from H&E images across ten tumor types, achieving moderate to high AUROC values.
medRxiv · Mar 8, 2023 · PreprintGenetic & Genomic Medicine