Adithya V. Madduri

Learning Minimal Gene Programs for Disease-Aligned Representations

This paper introduces SLMC to select minimal gene programs for disease-aligned representations in single-cell RNA-seq data, finding greedy methods outperform LASSO with small gene budgets.

A paradigm for skilled forelimb reaching by head-restrained mice

The paper presents a pipeline for head-restrained forelimb reaching in mice, including a pellet-presentation rig, training protocol, and analysis code, and demonstrates its ability to detect phase-dependent features of motor behavior.

Selection of Genetic Conditions for Multi-State Genomic Newborn Screening in BEACONS-NBS

The paper develops a comprehensive list of genetic conditions for genomic newborn screening, including 777 conditions associated with 743 genes, for implementation across multiple U.S. states and territories.

Protein Compositional Ratio Representation (PCRR)Systematically Improves Human Disease Prediction

The paper introduces PCRR, a method using protein ratio features to improve disease prediction in proteomics, showing significant gains in Alzheimer's classification and generalizability across datasets.