Serine 1283 in extracellular matrix glycoprotein Reelin is crucial for Reelin's function in brain development
Ralf B. KLEENE, Gabriele Loers, Ahmed Lotfy Sharaf, Shaobo Wang, Hardeep Kataria, Max Anstötz, Irm Hermans‐Borgmeyer, Melitta Schachner
This study shows that phosphorylation at serine 1283 in Reelin is critical for its function in brain development, as disrupting this site leads to neuronal migration defects and altered Reelin levels.
bioRxiv · Jan 6, 2022 · PreprintNeuroscience