Yihan Lin

isCORAL infers clonal relationships and cell-fate dynamics from single-cell and spatial transcriptomes, outperforming existing methods in lineage reconstruction and memory-gene identification.

The paper identifies transcriptional memory as the basis of heritable cellular states in cancer and stem cells, distinguishing between clustered and latent states.

This paper develops a method to monitor multiple gene expressions in single cells using ratiometric RNA labeling and applies it to study synthetic gene circuits.