Seung Hoan Choi

A genome-wide polygenic score identifies individuals with a 4-fold increased risk for coronary disease, similar to a rare monogenic mutation.

The paper uses whole genome sequencing to identify genetic variants associated with plasma lipoprotein(a) levels and finds high heritability and inter-ethnic differences in Lp(a) risk.

The paper describes the quality control and integration of genotype calls from two pipelines for whole genome sequencing data in the Alzheimer’s Disease Sequencing Project, resulting in a high-quality consensus dataset.

This study compares mRNA-Seq data from Huntington and Parkinson Diseases to identify common and unique transcriptional signatures, revealing shared inflammatory processes and differential biological pathway enrichments.