Adam Thomas Labadorf

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

The paper identifies prion synaptotoxic pathways and inhibitory drugs using phosphoproteomic and transcriptomic data from prion-treated neurons.

Proteomic Analysis of Human Chronic Traumatic Encephalopathy Brain Implicates Proteasome and Ribosome Dysfunction in Disease Progression

This study identifies proteomic changes in CTE brains, linking proteasome and ribosome dysfunction to disease progression and clinical features.

Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donors

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease

The paper quantifies transposable element RNA dynamics in aging human and mouse brains and neurodegenerative diseases, finding age-related changes and disease-specific TE RNA dysregulation.

Reading Outside the Lines: A Systematic Approach for Detecting Bias in Scientific Communication

This paper introduces FELIX, a tool to detect bias in scientific communication, showing it improves student understanding of social and ethical implications of research.

Heterogeneity of novel APOER2 isoforms specific to Alzheimer disease impact cellular and synaptic states

The paper identifies AD-specific APOER2 isoforms in human brain regions and shows they alter cell surface expression and synaptic function, potentially contributing to AD pathogenesis.

Inflammation and neuronal gene expression changes differ in early vs late chronic traumatic encephalopathy brain

The paper compares gene expression changes in early and late stages of chronic traumatic encephalopathy (CTE) and identifies factors influencing disease expression.

Holobiont transcriptomes for the critically endangered staghorn coral (Acropora cervicornis) from two environmentally distinct sites on Turneffe Atoll, Belize

The paper develops transcriptomes for two staghorn coral populations from Turneffe Atoll, Belize, to study gene activity across different taxa in the coral holobiont.

RNA-sequencing of human post-mortem hypothalamus and nucleus accumbens identifies expression profiles associated with obesity.

The paper identifies differentially expressed mRNAs and microRNAs in human brain tissues associated with obesity and BMI using RNA sequencing from multiple cohorts.

The Caudate Nucleus Undergoes Dramatic and Unique Transcriptional Changes in Human Prodromal Huntington’s Disease Brain

This study compares gene expression in asymptomatic Huntington’s disease carriers' caudate nucleus with symptomatic HD and healthy controls, identifying unique transcriptional changes in early stages of the disease.

Comparative Huntington And Parkinson Disease mRNA Analysis Reveals Common Inflammatory Processes

This study compares mRNA-Seq data from Huntington and Parkinson Diseases to identify common and unique transcriptional signatures, revealing shared inflammatory processes and differential biological pathway enrichments.