Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria
Khuram U. Ashraf, Mariana Batista, T. Bertie Ansell, Ankita Punetha, Stephannie Rosario-Garrido, Emre Firlar, Jason T. Kaelber, Phillip James Stansfeld, Vasileios I. Petrou
This study presents cryo-EM structures of ArnC, revealing its conformational changes and catalytic mechanism for aminoarabinose glycosylation in polymyxin resistance.
Nature Communications · Dec 9, 2025Peer-reviewedBiochemistry