Temporal dynamics of viral fitness and the adaptive immune response in HCV infection
Melanie Rose Walker, Preston Leung, Elizabeth Keoshkerian, Mehdi R Pirozyan, Andrew R. Lloyd, Fabio Luciani, Rowena Anne Bull
This study examines how viral fitness and immune responses interact in HCV infection, showing fitness decreases early but rebounds with mutations, and strong CD8+ T-cell responses drive chronic infection.
bioRxiv · Sep 7, 2024Immunology