Author

Ai Shinobu

The University of OsakaORCID 0000-0002-2865-6461Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Yichao WuiD· 2 shared Akira ImamotoiD· 1 shared Mariko OkadaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiophysics

Yichao WuORCID

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2 papers

Recent·Most cited

Trans-Allosteric Activation Releases Distinct Conformational Traps in Kinase Heterodimers

Akira Imamoto, Yichao Wu, Ai Shinobu, Mariko Okada

The paper introduces AlloQuant, a computational tool that quantifies kinase regulation by analyzing structural ensembles, and demonstrates its application to CDK1 and CSK to reveal distinct conformational mechanisms of activation.

bioRxiv · Sep 1, 2026 · PreprintBiophysics

Protein-peptide binding pathways revealed by two-dimensional replica-exchange molecular dynamics

Yichao Wu, Ai Shinobu

This study uses molecular dynamics to uncover binding pathways of a peptide to a kinase, identifying key intermediate states and guiding interactions.

bioRxiv · Apr 1, 2026 · PreprintBiophysics