Author

Akira Imamoto

University of ChicagoORCID 0000-0002-1009-9302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Mariko OkadaiD· 2 shared Ai ShinobuiD· 1 shared Andrey O. DemkiviD· 1 shared Ben E. CliftoniD· 1 shared Dariia YehorovaiD· 1 shared Gen‐ichiro UechiiD· 1 shared Michael RobinsoniD· 1 shared Paola LaurinoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

Mariko OkadaORCID

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2 papers

Recent·Most cited

Trans-Allosteric Activation Releases Distinct Conformational Traps in Kinase Heterodimers

Akira Imamoto, Yichao Wu, Ai Shinobu, Mariko Okada

The paper introduces AlloQuant, a computational tool that quantifies kinase regulation by analyzing structural ensembles, and demonstrates its application to CDK1 and CSK to reveal distinct conformational mechanisms of activation.

bioRxiv · Sep 1, 2026 · PreprintBiophysics

Minimal Perturbation of Activation Loop Dynamics Rewires KinaseSignaling

Prashant Jain, Dariia Yehorova, Ririn Rahmala Febri, Ben E. Clifton, Andrey O. Demkiv, Gen‐ichiro Uechi, Michael Robinson, Shina Caroline Lynn Kamerlin, Mariko Okada, Akira Imamoto, Paola Laurino

The paper identifies a triple-deletion mutant of SRC kinase that alters activation loop dynamics, leading to changes in substrate preference and signaling outcomes.

bioRxiv · Oct 15, 2025 · PreprintBiochemistry