Jana M. Weber

The Quagmire of Immunogenicity-Guided Antibody Design: Labels Limit Progress

The paper evaluates antibody design methods using immunogenicity labels and finds that format-based approaches outperform sequence-based predictors, but label inaccuracies limit progress.

All-Atom Protein Sequence Design using Discrete Diffusion Models

This paper introduces a discrete diffusion model for protein sequence design using all-atom representations, showing improved novelty and diversity compared to amino acid-based models.

Guiding diffusion models for antibody sequence and structure co-design with developability properties

This paper designs antibody sequences and structures using a diffusion model guided by developability properties like solubility and folding stability.