Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C.
Dazhi Li, Xinbo Wang, Bodan Hu, Hongyan Hao, Stephanie Hamill, Yuting Li, Guochao Chen, Pietro V. De Camilli, Karin M. Reinisch
The paper determines the structure of VPS13C using cryo-EM, revealing a lipid-transfer-nonpermissive conformation and identifying calmodulin as a regulatory partner.
bioRxiv · Nov 10, 2025 · PreprintCell Biology