Systematic identification of pan-cancer single-gene expression biomarkers in drug high-throughput screens
Ginte Kutkaite, Göksu Avar, Diyuan Lu, Thomas J. O’Neill, Daniel Krappmann, Michael P. Menden
The paper develops a regression framework to identify pan-cancer single-gene biomarkers of drug sensitivity in cell line screens, recovering known markers and identifying new ones for ERK/MAPK inhibitors.
PLoS ONE · May 11, 2026Peer-reviewedCancer Biology