BioinformaticsbioRxivPreprint
Projected Gradient Descent for Hallucination-Based Protein Binder Design
Magnus Ross, David M Miller, Jude Wells
This paper evaluates projected gradient descent (PGD) for hallucination-based protein binder design, finding it improves design efficiency and diversity compared to softmax-based methods.
DOI 10.64898/2026.10.22.760942