Inhibition of phosphodiesterase - 10A by Papaverine protects human cortical neurons from quinolinic acid-induced oxidative stress and synaptic proteins alterations
Abid Bhat, Vanessa X. Tan, Benjamin Heng, Musthafa Mohamed Essa, Saravana Babu Chidambaram, Gilles J. Guillemin
This study shows that papaverine inhibits PDE10A, reducing oxidative stress and protecting synaptic proteins in human cortical neurons exposed to quinolinic acid.
bioRxiv · Dec 4, 2020 · PreprintNeuroscience