Improving the discovery of rare variants associated with alcohol problems by leveraging machine learning phenotype prediction and functional information.
Mohammad Mehdi Ahangari, Amanda Elswick Gentry, Mohammed Falih Hassan, Tan Hoang Nguyen, Kenneth S. Kendler, Silviu‐Alin Bacanu, Roseann Elizabeth Peterson, Brien P. Riley, Bradley Todd Webb
This study uses machine learning and functional weights to identify rare variants associated with AUDIT-P, finding significant associations in ADH1C and THRA genes.
bioRxiv · Sep 11, 2023 · PreprintGenetics