Bradley Todd Webb

Rare copy number variation in Post-traumatic stress disorder using whole genome sequencing and biobank data

This study investigates rare copy number variants in PTSD using whole-genome sequencing and biobank data, finding significant associations in specific ancestry groups and gene-sets.

Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases.

The paper identifies FDA-approved drugs targeting genes associated with opioid use disorder by integrating multi-omic data and drug databases.

Trans-ancestry Genome-Wide Analyses in UK Biobank Yield Novel Risk Loci for Major Depression

This study conducts trans-ancestry GWAS on UK Biobank data to identify novel MDD risk loci, finding 61 loci with increased sample size and ancestry inclusivity.

Improving the discovery of rare variants associated with alcohol problems by leveraging machine learning phenotype prediction and functional information.

This study uses machine learning and functional weights to identify rare variants associated with AUDIT-P, finding significant associations in ADH1C and THRA genes.

Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific NRXN1 disruptions

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach

The paper analyzes rare functional variation in genes related to ethanol metabolism in severe alcohol dependence cases using a case-only design and WES data from the island of Ireland.

Differences in Genetic Correlations between Posttraumatic Stress Disorder and Alcohol Use Disorder-Related Phenotypes Compared to Alcohol Consumption-Related Phenotypes

The paper examines genetic correlations between PTSD and alcohol-related phenotypes, finding distinct genetic factors for AUD versus alcohol consumption.

Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.

This study uses BMI GWAS and genomic structural equation modeling to show that genetic influences on BMI remain stable from age 40 to 73 in men and women.

Missingness Adapted Group Informed Clustered (MAGIC)-LASSO: A novel paradigm for prediction in data with widespread non-random missingness

The paper develops MAGIC-LASSO to predict missing data in biobanks with non-random missingness, achieving high phenotypic and genetic correlations in UK Biobank AUDIT score predictions.

TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders

The paper introduces JEPEGMIX2-P, a TWAS pathway method that improves computational efficiency and performance for psychiatric disorder GWAS, showing increased power over existing methods like MAGMA.

Increasing the resolution and precision of psychiatric GWAS by re-imputing summary statistics using a large, diverse reference panel

This paper improves psychiatric GWAS by re-imputing summary statistics using a larger, more diverse reference panel, revealing new signals from rare variants.

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

DNA Methylation Associated with Postpartum Depressive Symptoms Overlaps Findings from a Genome-wide Association Meta-Analysis of Depression

The paper identifies DNA methylation regions associated with postpartum depressive symptoms and finds overlap with genome-wide association study results for depression.

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Twin Study of Early-Onset Major Depression Finds DNA Methylation Enrichment for Neurodevelopmental Genes

This study identifies DNA methylation changes in monozygotic twins linked to early-onset major depression, highlighting neurodevelopmental gene involvement.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Polygenic prediction of the phenome, across ancestry, in emerging adulthood

The paper constructs a polygenic risk atlas for 33 traits in emerging adults and finds genetic risks for schizophrenia, neuroticism, and depression predict various phenotypes.

JEPEGMIX2: improved gene-level joint analysis of eQTLs in cosmopolitan cohorts.

JEPEGMIX2 improves gene-level eQTL analysis by using updated cis-eQTL SNPs and adjusting for background enrichment, reducing false positives in cosmopolitan cohorts.