TGFBR2-High mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell function
Amanda Johnson, Harmon Singh Khela, Jack Korleski, Sophie Sall, Yun-Qing Li, Weiqiang Zhou, Karen Smith-Connor, Hernando López-Bertoni, John Laterra
The paper identifies TGFBR2-high mesenchymal glioma stem cells that mimic regulatory T cells and suppress T cell function, showing TGFBR2 inhibition can reverse this effect.
bioRxiv · Jan 7, 2025 · PreprintCancer Biology