Madeleine Chalifoux

The paper develops a generative model to study the first cell fate bifurcation in mammalian development, revealing stochastic dynamics and temporal heterogeneity in key transcription factors.

This study quantifies YAP dynamics during preimplantation embryo development, showing that cell cycle mechanisms, not mechanical perturbations, primarily regulate YAP levels for cell fate decisions.

The paper introduces a dataset and method for nuclear segmentation and tracking in mouse embryos, identifying Stardist-3D as the most accurate method for this task.