Eszter Pósfai

Cell cycle-dependent transitions in PCP protein mobility erase and restore planar cell polarity in mitosis

The paper shows PCP proteins transition between mobile and stable states during mitosis, losing and restoring planar cell polarity through lateral diffusion and adhesive interactions.

Generative model for the first cell fate bifurcation inmammalian development

The paper develops a generative model to study the first cell fate bifurcation in mammalian development, revealing stochastic dynamics and temporal heterogeneity in key transcription factors.

In vivo measurements of receptor tyrosine kinase activity reveal feedback regulation of a developmental gradient

The paper uses pYtag biosensors to measure RTK activity in Drosophila, revealing feedback regulation that shapes developmental gradients.

Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development

This study quantifies YAP dynamics during preimplantation embryo development, showing that cell cycle mechanisms, not mechanical perturbations, primarily regulate YAP levels for cell fate decisions.

Nuclear instance segmentation and tracking for preimplantation mouse embryos

The paper introduces a dataset and method for nuclear segmentation and tracking in mouse embryos, identifying Stardist-3D as the most accurate method for this task.

FGF2 and BMP4 influence on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryo

This study examines FGFR2 dynamics in mouse embryos, showing its correlation with PE cells increases during blastocyst development, supporting FGF's role in maintaining rather than initiating the PE lineage.

Efficient generation of targeted large insertions in mouse embryos using 2C-HR-CRISPR

The paper introduces 2C-HR-CRISPR, a method for efficiently generating targeted large insertions in mouse embryos, and demonstrates its use in creating fluorescent reporter mouse lines and assessing protein function.

MODELING SIGNALING-DEPENDENT PLURIPOTENT CELL STATES WITH BOOLEAN LOGIC CAN PREDICT CELL FATE TRANSITIONS

The paper develops a computational model using Boolean logic to predict pluripotent stem cell fate transitions in response to signaling inputs.