Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia
Liqiang Chen, Xue‐Jing Lv, Qing‐Huan Guo, Su‐Su Lv, Ning Lü, Jin Ming Yu, Wendong Xu, Yu‐Qiu Zhang
This study shows that TN activates ipsilateral hippocampal microglia, leading to anxiodepressive behaviors and LTP impairment via IL-1β and P2X7R.
bioRxiv · Apr 16, 2022 · PreprintNeuroscience