Molecular bases for USP48 cis-activity regulation and hyperactivation by Cushing's disease-associated mutations
Gai Ando, Yasutaka Tsujimoto, Kei Moritsugu, Keijun Kakihara, Akinori Kidera, Shozo Yamada, Masayuki Komada, Hidenori Fukuoka, Toshiaki Fukushima
This study identifies molecular mechanisms by which USP48 mutations in Cushing's disease enhance enzyme activity through structural changes in the catalytic domain and C-terminal region.
bioRxiv · Dec 28, 2025 · PreprintMolecular Biology