Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points
Uri Barenholz, Dan Davidi, Ed Reznik, Yinon M. Bar‐On, Niv Antonovsky, Εlad Noor, Ron Milo
The paper shows that autocatalytic cycles in E. coli central carbon metabolism require specific enzyme expression and substrate affinity constraints to maintain stable fluxes.
eLife · Feb 7, 2017Peer-reviewedSystems Biology