Ron Milo

The paper characterizes over 250 Rubisco variants from bacteria and archaea, showing they rarely exceed 30 reactions per second at 30°C and predicting rates for all sequenced variants using machine learning.

This study characterizes the kinetic properties of over 100 bacterial form I rubiscos to identify factors influencing carboxylation rates, finding that carboxysomes and cyanobacterial origins are associated with faster rates.

This study demonstrates the production of bioplastic PHB in engineered E. coli using CO2 and formate via the reductive glycine pathway, showing potential for electro-bioproduction.

The paper estimates the fraction of DNA from dying cells that becomes detectable in plasma, finding less than 10% of DNA from dying cells is detectable, with ratios varying widely among cell types.

This study identifies three genetic mutations enabling E. coli to grow autotrophically when combined with non-native enzymes for carbon fixation and energy production.

The paper demonstrates that a bacterial CO2 concentrating mechanism enables E. coli to fix CO2 from ambient air using 20 CCM genes.

The paper investigates why certain phosphorelay architectures are more common in nature by analyzing their information transmission and metabolic costs using mathematical models.

The paper re-examines tradeoffs between Rubisco kinetic parameters using data from ~300 organisms, finding that most correlations are attenuated and only one tradeoff model remains.

The paper shows that autocatalytic cycles in E. coli central carbon metabolism require specific enzyme expression and substrate affinity constraints to maintain stable fluxes.

The paper presents a minimalistic model explaining the coordinated increase in protein expression with growth rate, validated using E. coli proteomics data.

The paper revises the estimate of human and bacterial cell counts in the body, showing they are similar in number rather than a 10:1 ratio.