Insulin-degrading enzyme activity is modulated by interaction with pyrroline-5-carboxylate reductase 1
Eun Suk Song, Camila Camacho-Navas, Anwesha Goswami, Anmol Nayak, Karol Andrea Arizaca Maquera, Jing Chen, Stefan Stamm, Emilia Galperin, Louis B. Hersh, David W. Rodgers
The paper identifies PYCR1 as an interacting protein of IDE, showing that their interaction modulates IDE activity and may regulate mitochondrial IDE function.
bioRxiv · Jul 19, 2026 · PreprintBiochemistry