Phillip A. Karpowicz

Epithelial function of the circadian clock gene, Bmal1, in regulating the mucosa.

This study shows that Bmal1 in colon epithelial cells promotes mucus production and is essential for sex-specific tissue regeneration after injury.

Time restricted feeding ameliorates colitis through clock-dependent and nutrition-dependent processes

This study shows that a 12-hour time-restricted feeding regimen reduces colitis in mice through both clock-dependent and nutrition-dependent mechanisms.

Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon

The paper analyzes daily gene expression rhythms in the regenerating colon using single-cell transcriptomics, revealing cell-type specific patterns and identifying a resource for future studies.

Development of multi-species qPCR assays for a stress transcriptional profiling (STP) Chip to assess the resilience of salmonids to changing environments

The paper develops multi-species qPCR assays for a STP-Chip to assess salmonid resilience to environmental stressors, finding tissue and genus-specific amplification success across 8 species.

The Emergence of Circadian Timekeeping in the Intestine

This study tracks the emergence of the circadian clock in Drosophila intestine cells, showing it begins after development and is influenced by hormone signaling and stem cell differentiation.