Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven myopathy
Jer-En Hsu, Qingyang Zhao, Weiqiu Cheng, Hyun Min Kang, Susan V. Brooks, Myungjin Kim, Jun Hee Lee
This study combines histopathology and spatial transcriptomics to show that mTORC1 hyperactivation causes fiber-type-specific pathological changes in skeletal muscle.
JCI Insight · Aug 20, 2026Peer-reviewedPathology