Transcriptional downregulation of rhodopsin is associated with desensitization of rods to light-induced damage in a murine model of retinitis pigmentosa.
Shimpei Takita, Hemavathy Harikrishnan, Masaru Miyagi, Yoshikazu Imanishi
This study shows that mutant rhodopsin causes downregulation of wild-type rhodopsin and itself, reducing light-induced damage in a mouse model of retinitis pigmentosa.
Human Molecular Genetics · Oct 7, 2025Peer-reviewedNeuroscience