Unexpected antidepressant-like effects of temozolomide in a mixed sex-cohort of adult rats: role of hippocampal FADD protein
Laura Gálvez‐Melero, María Julia García-Fuster
This study shows temozolomide induces antidepressant-like effects in rats, associated with reduced hippocampal FADD, challenging the link between neurogenesis and antidepressant efficacy.
bioRxiv · Apr 27, 2026 · PreprintPharmacology & Toxicology