Jianghui Xiong

Dynamic alterations of DNA methylation and transcriptome in adaptation to and recovery from the space environment

The paper analyzes DNA methylation and transcriptome changes in astronauts during and after spaceflight, identifying epigenetic adaptations and recovery patterns.

AI-Generated Hallmarks of Aging and Cancer: A Computational Approach Using Causal Emergence and Dependency Networks

This paper generates and evaluates computationally derived hallmarks of aging and cancer using DNA methylation data, showing stronger disease associations at the hallmark level than individual genes.

Next Generation Aging Clock: A Novel Approach to Decoding Human Aging Through Over 3000 Cellular Pathways

This paper introduces aging clock models that predict age-related diseases by analyzing DNA methylation in specific cellular pathways, showing strong predictive power for conditions like Alzheimer's and atherosclerosis.

Utilizing Pre-trained Network Medicine Models for Generating Biomarkers, Targets, Re-purposing Drugs, and Personalized Therapeutic Regimes: COVID-19 Applications

The paper introduces a pre-trained network medicine model, SEMO, to predict COVID-19 severity using DNA methylation data and identifies potential nutraceuticals and biomarkers.

Mining the Selective Remodeling of DNA Methylation in Promoter Regions to Identify Robust Gene-Level Associations with Phenotype

This study introduces a method to identify robust gene-phenotype associations by analyzing DNA methylation remodeling in promoter regions, showing improved overlap and biological significance compared to traditional methods.