Author

Tapio Ala-Nissilä

Loughborough UniversityORCID 0000-0002-3210-3181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1

Frequent Co-Authors

Maryam GhasemitareiiD· 2 shared Annemie BogaertsiD· 1 shared Cristina Gyursanszky· 1 shared Hoda TaebiD· 1 shared Maksudbek YusupoviD· 1 shared Mikko KarttuneniD· 1 shared Tayebeh Ghorbi· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

Maryam GhasemitareiORCID

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2 papers

Recent·Most cited

Impact of viral membrane oxidation on SARS-CoV-2 spike protein transmembrane anchoring stability

Maryam Ghasemitarei, Cristina Gyursanszky, Mikko Karttunen, Tapio Ala-Nissilä

This study uses molecular dynamics simulations to show that partial oxidation of viral membrane lipids reduces SARS-CoV-2 spike protein anchoring stability, with full oxidation lowering the anchoring free energy by 23%.

Physical Chemistry Chemical Physics · Jan 1, 2026Peer-reviewedBiochemistry

Effect of cysteine oxidation in SARS-CoV-2 Spike protein on its conformational changes: insights from atomistic simulations

Maryam Ghasemitarei, Hoda Taeb, Tayebeh Ghorbi, Maksudbek Yusupov, Tapio Ala-Nissilä, Annemie Bogaerts

This study uses molecular dynamics simulations to show that cysteine oxidation in SARS-CoV-2 Spike protein increases energy barriers for conformational transitions, stabilizing the protein structure.

Scientific Reports · Feb 26, 2025Peer-reviewedBiophysics