Hoda Taeb

The paper develops a motif-based model to predict sequence variant effects in AR enhancers and identifies functional classes of transcription factors, validated against mutagenesis data and GWAS risk alleles.

The paper infers enhancer-specific transcription factor interactions from gene expression data using a biophysical model and validates it with simulated and experimental data.

This study uses molecular dynamics simulations to show that cysteine oxidation in SARS-CoV-2 Spike protein increases energy barriers for conformational transitions, stabilizing the protein structure.

The paper introduces a method to infer functional regulatory sites in enhancer sequences using STARR-seq data, showing it can identify local regulatory sites missed by global approaches.