Differentiable Spin-Center Diffusion Model Enables DEER-Guided Generative Pipeline of Weighted Protein Ensembles
Te‐Yu Kao, Jens Meiler, Hassane S. Mchaourab
This paper introduces a differentiable spin-center diffusion model to generate weighted protein ensembles from DEER spectroscopy data, enabling thermodynamic interpretation of conformational ensembles.
bioRxiv · Nov 1, 2026 · PreprintBioinformatics