Low level of viral intra-host diversity is associated with severe SFTS disease
Xuemin Wei, Hongfeng Li, Lintao Sai, Li Song, Xinyi Gao, Chao Li, Xinyu Zhang, Yuanyuan Shen, Shuo Li, Longkang Liu, Tanya Golubchik, Yifei Xu
The paper analyzes SFTSV intra-host diversity in patients with varying disease severity, finding lower diversity in severe cases despite higher viral loads and identifying iSNVs linked to replication and immunity.
bioRxiv · Apr 28, 2025 · PreprintPathology