Michele Invernizzi

This paper introduces OPES multithermal sampling to efficiently explore rare conformations in intrinsically disordered proteins, revealing transient tertiary structures in ACTR.

The paper introduces a benchmark for evaluating protein ensemble generators across ordered and disordered proteins and presents a new model that improves performance on disordered regions.

The paper improves protein stability prediction by modifying existing models with a self-derived term, enhancing their performance without additional training or data.